Vasculitis in Systemic Sclerosis

Vasculitis in Systemic Sclerosis

Systemic sclerosis (SSc) is a multiorgan connective tissue disease characterized by autoantibody production and fibroproliferative stenosis of the microvasculature. The vascoluopathy associated with SSc is considered to be noninflammatory, yet frank vasculitis can complicate SSc, posing diagnostic and therapeutic challenges. Here, we have reviewed the literature for reports of small-, medium-, ...

ANCA positive vasculitis in systemic sclerosis

Systemic Vasculitis During the Course of Systemic Sclerosis

Although the presence of antineutrophil cytoplasmic antibodies (ANCA) has been reported in patients with systemic sclerosis (SSc), the association of SSc and systemic vasculitis has rarely been described. We obtained information on cases of systemic vasculitis associated with SSc in France from the French Vasculitis Study Group and all members of the French Research Group on Systemic Sclerosis....

ANCA vasculitis in a patient with systemic sclerosis.

The development of vasculitis in patients with systemic sclerosis (SS) is a rare event and association. However, because they share similar clinical manifestations but a different etiopathogenic basis, the need to distinguish between inflammatory vasculitic damage or scleroderma vasculopathy can sometimes be a real dilemma that determines the clinical prognosis and therapeutic regimen for these...

Autoantibodies in Systemic Vasculitis

Systemic vasculitis is a heterogeneous group of disorders characterized by inflammation andnecrosis in the vessel wall. The diagnosis of a systemic vasculitis is challenging, because patients usually present a broad spectrum of manifestations that vary according to the predominant size of vessels affected, organs and systems involved, and the extent of the inflammatory process (1). In systemic ...